Pfizer Lidocaine Hydrochloride and Epinephrine Injection, USP

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Learn About Pfizer Lidocaine Hydrochloride and Epinephrine Injection, USP

Lidocaine Hydrochloride and Epinephrine Injection, USP is a sterile, nonpyrogenic solution of lidocaine hydrochloride and epinephrine in water for injection for parenteral administration in various concentrations. Made by Hospira, a Pfizer company. 

Sodium metabisulfite 0.5 mg/mL and citric acid, anhydrous 0.2 mg/mL added as stabilizers. The headspace of Lists 1209, 3177, 3178, 3181, 3182 and 3183 are nitrogen gassed. May contain sodium hydroxide and/or hydrochloric acid to adjust pH; pH is 4.5 (3.3 to 5.5). Multiple-dose vials contain methylparaben 1 mg/mL added as preservative. Single-dose ampuls and vials contain no bacteriostat or antimicrobial agent. Discard unused portion. Lidocaine is a local anesthetic of the amide type. Lidocaine Hydrochloride, USP is chemically designated 2-(diethyl-amino)-2',6'-acetoxylidide monohydrochloride monohydrate, a white powder freely soluble in water. 

Clinical Pharmacology

Mechanism of Action Lidocaine HCl stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.

Hemodynamics Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. With central neural blockade these changes may be attributable to block of autonomic fibers, a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system, and/or the beta-adrenergic receptor stimulating action of epinephrine when present. The net effect is normally a modest hypotension when the recommended dosages are not exceeded.

Pharmacokinetics and Metabolism Information derived from diverse formulations, concentrations and usages reveals that lidocaine HCl is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent. Except for intravascular administration, the highest blood levels are obtained following intercostal nerve block and the lowest after subcutaneous administration.

The plasma binding of lidocaine HCl is dependent on drug concentration, and the fraction bound decreases with increasing concentration. At concentrations of 1 to 4 mcg of free base per mL 60 to 80 percent of lidocaine HCl is protein bound. Binding is also dependent on the plasma concentration of the alpha-1-acid glycoprotein.

Lidocaine HCl crosses the blood-brain and placental barriers, presumably by passive diffusion.

Lidocaine HCl is metabolized rapidly by the liver, and metabolites and unchanged drug are excreted by the kidneys. Biotransformation includes oxidative N-dealkylation, ring hydroxylation, cleavage of the amide linkage, and conjugation. N-dealkylation, a major pathway of biotransformation, yields the metabolites monoethylglycinexylidide and glycinexylidide. The pharmacological/toxicological actions of these metabolites are similar to, but less potent than, those of lidocaine HCl. Approximately 90% of lidocaine HCl administered is excreted in the form of various metabolites, and less than 10% is excreted unchanged. The primary metabolite in urine is a conjugate of 4-hydroxy-2,6-dimethylaniline.

The elimination half-life of lidocaine HCl following an intravenous bolus injection is typically 1.5 to 2 hours. Because of the rapid rate at which lidocaine HCl is metabolized, any condition that affects liver function may alter lidocaine HCl kinetics. The half-life may be prolonged two-fold or more in patients with liver dysfunction. Renal dysfunction does not affect lidocaine HCl kinetics but may increase the accumulation of metabolites.

Factors such as acidosis and the use of central nervous system stimulants and depressants affect the central nervous system levels of lidocaine HCl required to produce overt systemic effects. Objective adverse manifestations become increasingly apparent with increasing venous plasma levels above 6 mcg free base per mL. In the rhesus monkey arterial blood levels of 18 to 21 mcg/mL have been shown to be threshold for convulsive activity.

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Pfizer Lidocaine Hydrochloride and Epinephrine Injection, USP Features:

  • Generic Equivalent to Xylocaine
  • Multiple dose glass flip-top vial
  • Red cap color
  • Store at 20° to 25°C (68° to 77°F)
  • Multiple-dose vials contain methylparaben 1 mg/mL added as preservative


Quantity Single Unit or 25/Box
Application Local Anesthetic
Container Type Multiple Dose Vial
Dosage Form Injection
Generic Drug Name Lidocaine HCl / Epinephrine
Strength 1% - 1:100,000
Type Infiltration and Nerve Block
Volume 20 mL

Shipping, Payment, & Returns


Bttn provides free shipping on all of our products. Expected delivery times range from 7-14 business days. 

Payment Options

Payments are accepted via card, check, or PO. 

If you are paying by check, please promptly send all checks to 146 N Canal St Suite 300, Seattle, WA 98103. 

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Return Policy

30-day return policy.

You can request a return up to 30 days after receiving your item. To be eligible for a return, your item must be in the same condition that you received it, unworn or unused, with tags, and in its original packaging. You’ll also need the receipt or proof of purchase. 

To start a return, you can contact us. If your return is accepted, we’ll send you a return shipping label, as well as instructions on how and where to send your package. Items sent back to us without first requesting a return will not be accepted. 

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Lidocaine FAQs

What is Lidocaine used for?

Lidocaine injection is used to cause numbness or loss of feeling for patients having certain medical procedures (by blocking certain nerves using the brachial plexus, intercostal, lumbar, or epidural blocking techniques). Lidocaine is a local anesthetic. It prevents pain by blocking the signals at the nerve endings in the skin. This medicine does not cause unconsciousness as general anesthetics do when used for surgery.1

How long does the lidocaine injection last?

Lidocaine is a fast acting drug and can begin working very quickly, in a little as four minutes and depending on the dose. It can last from 30 minutes to three hours. There are a number of variables such as size of dose, locality of injection and whether it is given with additional medications such as epinephrine, sodium chloride, or sodium hydroxide that impact its longevity.

What is lidocaine HCI and epinephrine used for?

Lidocaine and epinephrine are often used together in dentistry and wound care scenarios. Epinephrine is used to constrict blood vessels, which is hypothesized to reduce bleeding, In practice, using epinephrine in conjunction with lidocaine prevents the blood vessels from taking the anesthetic drug away from where it is needed. Thus, including epinephrine makes these very short-acting drugs have a long enough duration to last through getting a tooth filled or pulled or having a wound stitched.

How is lidocaine injection given?

A healthcare provider will give you this injection. When used to treat heart rhythm problems, lidocaine is given as an infusion into a vein. When used as a local anesthetic, lidocaine is injected through the skin directly into the body area to be numbed. Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving lidocaine injection in a hospital setting. If you are being treated for irregular heart rhythm, your heart rate will be constantly monitored using an electrocardiograph or ECG (sometimes called an EKG). This will help your doctor determine how long to treat you with lidocaine injection.3